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CPS653 Chang-Yun L.
            and choose more reasonable models which follow the effect heredity principle.
            The Markov chain Monte Carlo and Gibbs sampling are applied and a general
            WinBUGS code that can be used for any SPDS and BDS designs is provided.
            Simulation studies are conducted and results show that the proposed SSVS
            method  well  controls  the  false  discovery  rate  and  has  higher  detection
            capability than the regression methods.

            2.  Models and estimations
                For an m-factor SPDS (or BDS) design with w whole plots (or blocks), let
              denote the response from the th run in the th whole plot (block), where
             
                                                                                     (1)
             = 1, … , ,  = 1, … ,  , and   is the size of the th whole plot (block). Then
                                        
                                 
            the full second-order model for the SPDS (BDS) design can be written as
                                      −1                 
                  =  + ∑     + ∑ ∑            + ∑   2  +  +  ,
                  
                        0
                                                                                
                                                                            
                                                                    ,
                                 ,
                                                   , ,
                            =1        =1  =+1         =1
            where   is the intercept,  ,  is the level of factor   for the th run in the th
                    0
                                                               
            whole plot (block),   and   are the main effect and quadratic effect of factor
                                       
                                
             , respectively,   is the interaction of factors   and  ,   is the random
                                                                        
                                                                     
                                                             
                              
              
            effect for the th whole-plot (block), and   is the random error for the th run
                                                    
            in the th whole plot (block). It is assumed that   and   have zero means with
                                                                 
                                                          
            variances   and  , respectively, and are mutually independent. Equation (1)
                       2
                               2
                       
                              
            can  be  further  expressed  in  the  form  of  matrices  as  follows.  Let   =
                                    ′
              11 12,…, (  −1) , 
            (              ) be  the    ×  1  vector  of  responses,  where   =
                                                                  ′
            (∑    ,  = (  , … ,  ,  , … ,  (−1) ,  , … ,   )  be  the  (1 + ) × 1
                            0, 1
                                                       11
                                        12
                                    
                   
               =1
            vector  of  the  intercept  and  fixed  effects,  where    =  2 + ( − 1)/
            2,  be the  × (1 + )  model  matrix  corresponding  to  ,   = ( ,· · ·
                                                                                   1
             ,  )  be the   ×  1  vector of the random whole-plot (block) effects, U be the
                 ′
               
              ×      indicator     matrix      corresponding      to       and  =
                                      ′
            ( ,  , … ,  (  −1) ,    ) be the   ×  1 vector  of  the  random  errors.  Then
                  12
              11
            Equation (1) can be expressed as

                                                            =  +  + .
                                                    

            If   and   are known, the GLS estimate for  is
               
                      

                                    ̂
                                           ′ −1
                                                 −1 ′ −1
                                                    = ( Σ  Χ) Χ Σ                                                (2)

            and the covariance matrix of  is
                                         ̂

                                                  −1
                                            ′ −1
                                                     = ( Σ  Χ) ,                                                      (3)

            Where  ∑ =  UU +  I (I is an  x  identity matrix)  is  the  covariance
                                   2
                              ′
                          2
                                        
                                    
                          
            matrix of . In practice,   and   are usually unknown and can be estimated
                                     
                                            
            using the REML method. By replacing Σ in (2) and (3) with Σ = ̂ UU + ̂ I ,
                                                                               ′
                                                                     ̂
                                                                           2
                                                                                    2
                                                                           
                                                                                     
            we obtain   = (X′∑ X) X ∑ y and V = (X ∑ X)  . Although it is known
                       ̂
                                    −1 ′ ̂ −1
                               ̂ −1
                                                  ̂
                                                               −1
                                                         ′ ̂ −1
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