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IPS192 Hukum C. et al.
            function  (, , )  in  (5)  uses  truncated  polynomial  spline  basis  functions.
                                
                                              
            {1, , … . ,  , ( −  ) , … . , ( −  )  }. Other basis functions, e.g. B-splines
                      
                              1 +
                                             +
            (Eilers and Marx, 1996) or radial functions, can also be used. Using a large
            number  of  knots  in  expression  (5)  can  lead  to  an  unstable  fit.  In  order  to
            overcome this problem, a penalty is usually put on the magnitude of the spline
            parameters γ.
                 When  geographically  referenced  responses  play  a  central  role  in  the
            analysis and need to be converted to maps, we can use bivariate smoothing,
            ( ,  ) = ( ,  , , ) where   and   are spatial coordinates. This is
                1
                   2
                            1
                                2
                                               1
                                                       2
            usually the case with environmental, agricultural, public health and poverty
            mapping  applications.  Consequently  we  assume  the  following  model
            (Opsomer et al., 2008)
                               ( ,  , , ) =  +   +   +  ,                      (6)
                                                                     
                                  1
                                                 0
                                                      1 1
                                      2
                                                             2 2
            where   is the -th row of the following  ×  matrix
                    
                                 = [( −  )] 1<< [( −  ′)] −1/2  ,                       (7)
                                         
                                              
                                                          
                                                                 1<<
                                                              
                                                1<<
            Where () = ‖‖ log‖‖,  = ( ,  ) and  ( = 1, … , ) are knots. Note
                              2
                                        
                                              1
                                                  2
                                                           
            that  the  C(t)  function  is  defined  so  that  when  there  is  a  knot  at  every
            observation (that is, the full rank case) this model for bivariate smoothing leads
            to a thin plate spline (Green and Silverman, 1994). The second matrix on the
            right-hand  side  of  (7)  applies  a  linear  transformation  to  the  radial  basis
            functions defining the first matrix, and was recommended by Ruppert et al.
            (2003) as a way of making the radial spline behave approximately like a thin
            plate spline. More details on the Z matrix can be found in Ruppert et al. (2003,
            chapter 13). As suggested by Ruppert et al. (2003), fitting the approximation
            (5) can be simplified by treating the vector γ as a random-effect vector in a
            mixed model specification, which allows estimation of β and γ by maximum
            likelihood  methods.  Following  Opsomer  et  al.  (2008),  Wand  (2003)  and
            Ruppert et al. (2003, chapter 4), the spline approximation to (4), and to (6), can
            be written as
                                        () =  ƞ =  +  + .                                         (8)
            If  other  covariates  are  available,  they  can  be  included  in  the  model  as
            parametric terms, by being added to the matrix X. In this model  is assumed
            to be a Gaussian random vector of dimension . In particular, it is assumed
            that  ~  (0, ∑ =   ), where  denotes the identity matrix of dimension
                                 2
                            
                      
                                              
                                  
            . Here  is the -vector of random area effects. As usual, it is assumed that
            the  area  effects  in    are  distributed  independently  of  the  spline  effects  in
             with  ~  (0, ∑ =   ). Under (8), a plug-in spatially non-linear empirical
                                   2
                        
                                    
                              
            predictor (SNLEP) for the total count   in area  is given by
                                                 
                                 ̂    =  + ( −  )̂   ,                                    (9)
                                                  
                                           
                                                      
                                       ̂
                                                 
                                     
                                           
            Where  ̂    = expit(  +  ̂ +  ̂)  for  binary  data  and  ̂    =
                                     
                                           
                                                 
                    ̂
                                                           
            exp(  +  ̂ +  ̂) for count data, and  ,   and   donate respectively
                                                                  
                  
                               
                                                        
                        
                                                           
                        
                              
                                                        
                  
                                                                  
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